The instructions on the Wiki were not complete enough to make transit a breeze for myself. The following is what I did with great success:

• Locate the nearest place to purchase a CharlieTicket/CharlieCard
  
• Purchase transit credits; I opted for the 7-Day unlimited so I have a fixed cost of only $15
• Board the closest Silver Line T Bus (Airport Terminals) directly outside of baggage claim.
  
• Exit the Silver Line at South Station
• Take the Red Line towards "Alewife"
• Exit the Red Line at the Kendall/MIT Station

The hotel is directly outside of the Red Line. Very awesome.